Here's my Lefty Automatic. I switched the strap on it for this photo.
Believe it or not, the watch is not too comfortable on. And here's why. I'm lefty. I wear my watches on my right wrist. Normal watches have the crown and pushers on the right side. When I wear a watch, the crown and pushers are pointing towards my elbow. When I bend my wrist there is nothing in the way.
When wearing the Lefty, the crown is on the left side. When I bend my wrist, it digs into my arm. Not comfortable. I also own a Russian Diver and it doesn't bother me since the crown is on the right side and doesn't dig into me.
Ironic, the lefty watch is LESS comfortable than the right-handed versions.